Duac Use In Pregnancy & Lactation

Use in pregnancy: There are no well-controlled studies in pregnant women treated with topical Duac gel. There are limited data on the use of topical clindamycin or benzoyl peroxide alone in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. No effects during pregnancy are anticipated since systemic exposure to clindamycin and benzoyl peroxide is low (see Pharmacology under Action). However, Duac should be used during pregnancy only if the expected benefit justifies the potential risk to the fetus.
Use in lactation: Duac has not been studied during breastfeeding. Percutaneous absorption of this drug is low. However, it is not know whether clindamycin or benzoyl peroxide is excreted in human milk after topical application. Clindamycin is excreted in human milk following oral and parenteral administration. Duac should be used during lactation only if the expected benefit justifies the potential risk to the infant. To avoid accidental ingestion by the infant if used during lactation, Duac should not be applied to the breast area.