Levonat Dosage/Direction for Use

Levofloxacin (Levonat) for intravenous infusion should be used immediately (during 3 hours) after perforation of rubber stopper. Protection from light during infusion is not required.
At room light solution for intravenous infusion can be stored maximum for 3 days not protected from light.
Considering biological equivalence of oral and parenteral dosage forms posology can be the same.
Dosing depends on severity and type of infection.
In adults with unimpaired renal function and creatinine clearance over 50 mL/minute, the following doses are recommended: See Table 5.

Click on icon to see table/diagram/image

As levofloxacin is primarily eliminated renally, the dose should be decreased in patients with impaired renal function. (See Table 6.)

Click on icon to see table/diagram/image

Doses for patients with impaired hepatic function: No dose adjustment required, as levofloxacin is metabolized in the liver to insignificantly.
Doses for elderly patients: If the renal function is unimpaired, no adjustment required.
The solution for intravenous administration is infused slowly, by drop infusion, intravenously. The minimum infusion time for one vial of levofloxacin (Levonat).
(100 mL of intravenous solution containing 500 mg of levofloxacin) should be not less than 60 minutes.
Depending on the patient's condition, intravenous administration can be replaced by oral administration after several days, while maintaining the dose.
The therapy duration depends on the progression of the disease. As with other antibacterial drugs, the recommendation is to continue levofloxacin (Levonat).
Treatment during at least 48-72 hours after the body temperature is normalized or after microbiologically proven death of infection agents.