Levonat Drug Interactions

Effect of other medicinal products on levofloxacin (Levonat): Theophylline, fenbufen or similar non-steroidal anti-inflammatory medicinal products: Pharmacokinetics of interaction between levofloxacin and theophylline was not identified. However significant decrease of seizure threshold is possible at concomitant use of quinolones and theophylline, non-steroidal anti-inflammatory drugs and other agents which reduce seizure threshold. Levofloxacin concentration in the presence of fenbufen was approximately by 13% higher than at administration of levofloxacin alone.
Probenecid and cimetidine: Effect of probenecid and cimetidine on elimination of levofloxacin is statistically significant. Renal clearance of levofloxacin is decreased in the setting of cimetidine by 24%, and probenecid by 34%. It happens as both drugs are able to block tubular secretion of levofloxacin. However, at doses tested in study, it is not probable that statistically significant kinetic differences had clinical significance. Caution should be treated to concomitant use of levofloxacin with medicinal products, effecting tubular secretion, such as probenecid and cimetidine, especially in patients with renal failure.
Other information: Clinical studies of pharmacology have shown no significant clinical effect on pharmacokinetics of levofloxacin at administration of levofloxacin together with the following medicinal products: calcium carbonate, digoxin, glibenclamide, ranitidine.
Effect of levofloxacin (Levonat) on other medicinal products: Cyclosporine: Half-life period of cyclosporine is increased by 33% at concomitant use with levofloxacin.
Vitamin K antagonists: At concomitant use with vitamin K antagonists (e.g., warfarin), elevation of coagulation tests (PT/International Normalized Ratio) and/or bleeding that could be expressed were reported. Taking this fact into account, patients who took concurrent vitamin K antagonists should monitor coagulation factors (see Precautions).
Medicinal products that prolong QT interval: Levofloxacin, as other fluoroquinolones, should be used with caution in patients who obtain medicinal products known for their ability to prolong QT interval (e.g., Class ІА and III antiarrhythmic agents, tricyclic antidepressants and macrolides). (See QT interval prolongation under Precautions).