Losarite Adverse Reactions

The most frequently reported adverse effects with losartan potassium + HCTZ include dizziness, upper respiratory infection, cough, and back pain.
Losartan potassium: Infections and infestations: Infection.
Blood and lymphatic system disorders: Anemia, hemolysis, thrombocytopenia (rare).
Immune system disorders: Hypersensitivity reactions, anaphylactic reactions, angioedema (including swelling of the larynx and glottis, causing airway obstruction and or swelling of the face, lips, pharynx, and/or tongue), vasculitis including Henoch-Schönlein purpura (rare).
Endocrine disorders: Diabetic vascular disease.
Metabolism and nutrition disorders: Anorexia, gout, hyperkalemia, hypoglycemia, hyponatremia, weight gain.
Psychiatric disorders: Anxiety disorder, anxiety, confusion, depression, dream abnormality, insomnia, memory impairment, panic disorder, sleep disorder.
Nervous system disorders: Cerebrovascular event/cerebrovascular accident (CVA), dizziness, dysgeusia, headache, hypoesthesia, migraine, nervousness, paresthesia, peripheral neuropathy, somnolence, tremor.
Eye disorders: Blurred vision, burning/stinging in the eye, cataract, conjunctivitis, decreased visual acuity.
Ear and labyrinth disorders: Tinnitus, vertigo.
Cardiac disorders: Angina pectoris, arrhythmias, atrial fibrillation, myocardial infarction, palpitation, second degree AV block, sinus bradycardia, sternalgia, syncope, tachycardia, ventricular fibrillation, ventricular tachycardia.
Vascular disorders: Hypotension/orthostatic hypotension (including dose-related orthostatic effects).
Respiratory, thoracic and mediastinal disorders: Bronchitis, cough/dry cough, dyspnea, epistaxis, laryngitis, nasal congestion, pharyngeal discomfort, pharyngitis, respiratory congestion, rhinitis, sinus disorder, sinusitis, upper respiratory infection.
Gastrointestinal disorders: Abdominal pain, constipation, dental pain, diarrhea, dry mouth, dyspepsia, flatulence, gastritis, nausea, obstipation, pancreatitis, vomiting.
Hepatobiliary disorders: Hepatitis (rare), liver function abnormalities.
Skin and subcutaneous tissue disorders: Alopecia, cellulitis, dermatitis, dry skin, ecchymosis, erythema, erythroderma, flushing, photosensitivity, pruritus, rash, sweating, urticaria.
Musculoskeletal and connective tissue disorders: Arthralgia, arthritis, coxalgia, fibromyalgia, joint swelling, muscle cramps, muscle weakness, myalgia, pain (back, arm, shoulder, hip, leg, knee, musculoskeletal), rhabdomyolysis (rare), stiffness.
Renal and urinary disorders: Nocturia, renal failure, renal impairment, urinary frequency, urinary tract infection.
Reproductive system and breast disorders: Decreased libido, erectile dysfunction/impotence.
General disorders and administration site conditions: Asthenia, chest pain, edema/swelling, facial edema, fatigue, fever, influenza-like disease, malaise.
Investigations: Increases in alanine aminotransferase (ALT), BUN, serum creatinine, serum potassium, liver enzymes, and bilirubin; decreases in hemoglobin and hematocrit.
Hydrochlorothiazide: Neoplasms benign, malignant and unspecified (including cysts and polyps): Non-melanoma skin cancer (basal cell carcinoma and squamous cell carcinoma).
Blood and lymphatic system disorders: Agranulocytosis, aplastic anemia, bone marrow failure, granulocytopenia (rare), hemolytic anemia, leukopenia, neutropenia, thrombocytopenia.
Immune system disorders: Hypersensitivity reactions, anaphylactic reactions.
Endocrine disorders: Worsening of diabetic control.
Metabolism and nutrition disorders: Anorexia, decreased appetite, electrolyte imbalance, hypercalcemia, hypercholesterolemia, hyperglycemia, hyperuricemia, hypochloremic alkalosis, hypokalemia, hypomagnesemia, hyponatremia, hypophosphatemia, hypovolemia.
Psychiatric disorders: Insomnia, nervousness.
Nervous system disorders: Cephalgia, dizziness, headache, lightheadedness, paresthesia, restlessness, vertigo.
Eye disorders: Acute myopia, acute angle-closure glaucoma, transient blurred vision, visual impairment, xanthopsia.
Cardiac disorders: Cardiac arrhythmias.
Vascular disorders: Hypotension/orthostatic hypotension.
Respiratory, thoracic and mediastinal disorders: Respiratory distress (including pneumonitis and pulmonary edema).
Gastrointestinal disorders: Constipation, cramping, diarrhea, gastric irritation, gastrointestinal discomfort, nausea, pancreatitis, sialadenitis, spasms, vomiting.
Hepatobiliary disorders: Jaundice (intrahepatic cholestatic jaundice).
Skin and subcutaneous tissue disorders: Alopecia, cutaneous lupus erythematosus, erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, necrotizing angiitis (vasculitis and cutaneous vasculitis), photosensitivity reactions, purpura, rash, reactivation of cutaneous lupus erythematosus, urticaria.
Musculoskeletal and connective tissue disorders: Muscle cramps, muscle spasm.
Renal and urinary disorders: Glycosuria, interstitial nephritis, renal dysfunction, renal failure.
Reproductive system and breast disorders: Impotence.
General disorders and administration site conditions: Asthenia, fever, weakness.
Investigations: Increased total cholesterol, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglycerides.