Hypersensitivity to losartan potassium, HCTZ, other sulfonamide derivatives, or to any component of the product.
Therapy resistant hypokalemia or hypercalcemia.
Severe hepatic impairment, cholestasis and biliary obstructive disorders.
Refractory hyponatremia.
Symptomatic hyperuricemia/gout.
Pregnancy.
Severe renal impairment (creatinine clearance <30 mL/min).
Anuria.
Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment [glomerular filtration rate (GFR) <60 mL/min/1.73 m2].