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Pregnancy: Pregnancy Category D (see Fetal Toxicity under Warnings and Losartan potassium: Fetal Toxicity under Precautions). Angiotensin II receptor antagonists should not be used during pregnancy. When pregnancy is diagnosed, immediately discontinue treatment with losartan, and, if appropriate, alternative treatment should be started.
Thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia and possibly other adverse reactions that have occurred in adults.
Lactation: It is not known whether losartan is distributed in human milk. Thiazides appear in human milk. Discontinue breastfeeding or drug due to potential risk to breastfeeding infants, taking into consideration the importance of the drug to the mother.
