Doses higher than those recommended entail the risk of very serious liver damage hepatic injury, including the rise of liver failure and death. Clinical signs and symptoms of liver damage (including fulminant hepatitis, hepatic failure, cholestatic hepatitis, cytolytic hepatitis) are usually first seen after two days of drug administration with a peak seen, usually after 4-6 days. Treatment with antidote should be given as soon as possible.
Use in Pregnancy & Lactation: See Use in Pregnancy & Lactation for further information.