Zepime Dosage/Direction for Use

Cefepime is given as the hydrochloride by deep intramuscular injection, or intravenously by infusion over at least 30 minutes. Doses are expressed in terms of the equivalent amount of Cefepime. The usual dose 1 to 2 g daily in 2 divided doses for mild to moderate infections, increased to 4g daily in 2 divided doses in severe infections, although up to 6 g daily in 3 divided doses has been given for febrile neutropenia. Children aged over 2 months and weighing up to 40 kg may be given 50 mg per kg body weight twice daily; this dose may be given three times daily for febrile neutropenia.
Dosage should be modified in renal impairment. After a normal initial loading dose the maintenance dosage should be adjusted according to the patient's creatinine clearance and the severity of the infection: creatinine clearance 30 to 60 mL per minute, 0.5 to 2 g every 24 hours; 11 to 29 mL per minute, 0.5 to 1 g every 24 hours; and 10 mL per minute or less, 0.25 to 0.5 g every 24 hours.
Patients undergoing haemodialysis should be given a dose after each dialysis sessions, while those undergoing continuous ambulatory peritoneal dialysis should receive normal recommended doses at intervals of 48 hours.
Or as prescribed by the physician.