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Cefepime is a fourth generation cephalosporins and about 10% of penicillin-sensitive patients may also be allergic to cephalosporins although the true incidence is uncertain; great care should be taken if Cefepime is to be given to such patients. Care is also necessary in patients with history of allergy.
Cefepime should be given with caution to patients with renal impairment; a dosage reduction may be necessary. Renal and haematological status should be monitored especially during prolonged and high-dose therapy. Other cephalosporins and cephamycins (ceforanide, cefotetan, cefoxitin, and cefpirome) may interfere with the Jaffe method of measuring creatinine concentrations and may produce falsely high values; this should be borne in mind when measuring renal function.
