The use of nephrotoxic drugs such as the aminoglycosides gentamicin and tobramycin may increase the risk of kidney damage with Cefepime. There is also some evidence for enhanced nephrotoxicity with the loop diuretic furosemide, but this is less certain than for furosemide with cefaloridine. Similarly to the penicillins, the renal excretion of Cefepime and many other cephalosporins is inhibited by probenecid. There may be antagonism behavior Cefepime and bacteriostatic antibacterials.
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