Belcid Drug Interactions

BELCID SUSPENSION may interfere with drugs by: Increasing the gastric pH altering disintegration, dissolution, solubility, ionization and gastric emptying time. Absorption of weakly acidic drugs is decreased, possibly resulting in decreased drug effect (e.g. digoxin, phenytoin, chlorpromazine, isoniazid, chlordiazepoxide, indomethacin, iron salts). Doses of these drugs should be spaced as far apart as possible from doses of BELCID SUSPENSION. Weakly basic drug absorption is increased possibly resulting in toxicity or adverse reactions (e.g. pseudoephedrine, levodopa).
Adsorbing or binding drugs to their surface resulting in decreased bioavailability (e.g. tetracycline); therefore, doses of tetracyclines should be spaced 1-2 hours from doses of BELCID SUSPENSION.
Increasing urinary pH affecting the rate of drug elimination. The effect is inhibition of the excretion of basic drugs (e.g. quinidine, amphetamines) and enhanced excretion of acidic drugs (e.g. salicylates).