IM Adult & childn >12 yr 1-2 g once daily every 24 hr. Max: 4 g once daily in severe cases. Usual duration of therapy: 4-14 days. Infant & childn (3 wk-12 yr) 20-80 mg/kg once daily. Neonate up to 2 wk 20-50 mg/kg once daily. Max: 50 mg/kg daily. Bacterial meningitis Infant & childn Initially 100 mg/kg once daily. Max: 4 g daily. Treatment duration: Neisseria meningitidis: 4 days, H. influenzae: 6 days, Strep pneumoniae: 7 days. Gonorrhoea 250 mg as single dose. Hepatic & renal impairment Max: 2 g daily.
Not to be administered IV. Discontinue if mild colitis occurs. Penicillin-sensitive patients. Pseudomembranous colitis. Preexisting gall bladder, biliary tract, liver or pancreatic disease. Monitor prothrombin time & administer exogenous vit K. Hepatic & renal impairment. Pregnancy & lactation. Not to be administered in premature hyperbilirubinemic neonates.
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