Ceftrex Drug Interactions

Probenecid: Concomitant administration of oral probenecid (500 mg daily) does not appear to affect the pharmacokinetics of ceftriaxone.
Aminoglycosides: In vitro studies indicate that the antibacterial activity of ceftriaxone and aminoglycosides may be additive or synergistic against some strains of Enterobacteriaceae and some strains of Pseudomonas aeruginosa.
Alcohol: A disulfiram-like reaction may occur. However, this effect generally has been reported only with β-lactam antibiotics that contain an N-methylthiotetrazole (NMTT) side chain. That ceftriaxone does not contain these side chain.
Loop diuretics: Use CEFTREX with caution in patients receiving potent diuretics (e.g. loop diuretics). The risk of nephrotoxicity may be increased. Monitor renal function.
Drug/Lab test interaction: Immunohematology test: A false-positive direct Coombs' test has occurred in some patients receiving ceftriaxone, in hematologic studies, in transfusion cross-matching procedure.
Test for urinary glucose: Like most cephalosporins, ceftriaxone interferes with urinary glucose determinations using cupric sulfate (e.g. Benedict's solution, Clinitest). A false-positive reaction may occur but not with enzyme-based tests such as clinistix.