Ceftrex Dosage/Direction for Use

Intramuscular injection: CEFTREX 1 g is dissolved in 3.5 ml of 1% lidocaine solution and administered by deep intragluteal injection. It is recommended that not more than 1 g be injected on either side. *The lidocaine solution must never be administered intravenously.
Standard dosage: Adults and children over 12 years: Administered 1 - 2 g once daily (every 24 hours) in severe cases the dosage may be raised to a maximum dose of 4 g administered once daily.
Infants and children (three weeks to 12 years): 20 - 80 mg/kg body weight administered once daily.
Neonates (up to two weeks): 20 - 50 mg/kg body weight, administered once daily (not to exceed 50 mg/kg/day).
Dosage in renal and hepatic impairment: Modification of the usual dosage of ceftriaxone generally in unnecessary in patients with impaired renal or hepatic function alone; however, serum concentrations of the drug should be monitored when ceftriaxone is used in patients with severe renal impairment and in patients with both hepatic and substantial renal impairment. If evidence of accumulation of the drug occurs, dosage should be decreased accordingly. Dosage in adults with both hepatic and substantial renal impairment should not exceed 2 g daily unless serum concentrations of the drug are monitored closely.
Because ceftriaxone is not removed by hemodialysis, supplemental doses of the drug are unnecessary during or after dialysis.
Duration: Generally, ceftriaxone therapy should be continued for at least 2 days after the signs and symptoms of infection have disappeared. The usual duration of therapy is 4 to 14 days; in complicated infection, longer therapy may be required.
Special dosage: In bacterial meningitis in infants and children, treatment begins with doses of 100 mg/kg body weight (not to exceed 4 g) once daily. The duration of therapy is as the following: Neisseria meningitidis 4 days, Streptococcus pneumoniae 7 days, Haemophilus influenzae 6 days.
For the treatment of Gonorrhea: A single IM dose of 250 mg is advised.
Direction for use: Reconstituted solutions retain their physical and chemical stability for six hours at room temperature (or 24 hours at 5°C). As a general rule; however, the solutions should be used immediately after preparation. They range in color from pale yellow to amber, depending on the concentration and the length of storage. This characteristic of the active ingredient is of no significance for the efficacy or tolerance of the drug.