Inappropriately large doses may cause seizures, particularly in renal impairment. Reduce dosage when renal function is impaired. If seizures occur, promptly discontinue the drug, administer anticonvulsants if clinically indicated. Ceftriaxone is not removed by hemodialysis or peritoneal dialysis, and these procedures would be ineffective in reducing ceftriaxone concentrations following overdosage. There is no specific antidote. If acute overdosage of ceftriaxone occurs, supportive and symptomatic treatment should be initiated.
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