Favotan Dosage/Direction for Use

The recommended dose of this product is one tablet per day. This product can be taken with or without food. Take this drug with water. It is recommended to take this drug at the same time each day (e.g. every morning).
Dose titration with individual components (i.e. amlodipine and losartan) is recommended before taking this drug. When monotherapy for individual components fails to control a patient's blood pressure, however, direct change to this drug may be considered in cases as follows: 5/50 mg tab: For patients whose blood pressure is not adequately controlled with amlodipine 5 mg or losartan 50 mg alone.
5/100 mg: For patients whose blood pressure is not adequately controlled with amlodipine 5 mg or losartan 100 mg alone.
For convenience, patients receiving losartan and amlodipine from separate tablets/capsules may be switched to this product containing the same individual components.
Renal impairment: No dosage adjustment is required for patients with mild to moderate renal impairment (e.g. creatinine clearance: 20-50 mL/min). This product is not recommended for use in patients with moderate or severe renal impairment (e.g. creatinine clearance: <20 mL/min) and dialysis patients.
Patients with intravascular volume-depletion: This product is not recommended for patients with intravascular volume depletion (e.g. patients under treatment with high dose of diuretics). (Please note Warnings.)
Patients with hepatic impairment: Among patients with anamnesis of hepatic impairments, this product is not recommended for whom require the reduction of losartan (e.g. 25 mg, once daily).
Elderly patients: This product is not recommended for initial treatment for elderly patients with the age of 75 or more because the recommended initial dose of losartan is 25 mg, once daily.
Pediatric patients: This product is not recommended for patients under the age of 18 due to the lack of data on safety and efficacy for them.
Children and Pediatric Use: This drug is not recommended for pediatric patients under the age of 18 due to the lack of data on safety and efficacy for them.
Geriatric Use: This product is not recommended for initial treatment for elderly patients with the age of 75 or more because the recommended initial dose of losartan is 25 mg, once daily.
Effect on Clinical Test: Pulse rate and laboratory test conducted alter 8 weeks of amlodipine/losartan treatment have shown delayed pulse when comparing to baseline, without clinical significance. Elevations in serum creatinine and hepatic enzyme have been observed in some patients, but the symptoms didn't require the monitor of specific clinical test data.