Favotan Overdosage

OVERDOSE AND TREATMENT: No overdose regarding this drug has been reported. Amlodipine or losartan overdose cases are as follows: Amlodipine: Overdose with amlodipine may result in excessive peripheral vasodilation and, possibly, reflex tachycardia. In addition, fatal consequences that led to shock state or caused shock have been observed because of marked and potentially prolonged systemic hypotension that lasted for a long time. The administration of activated charcoal to healthy volunteers immediately or up to two hours after ingestion of amlodipine 10 mg has significantly decreased amlodipine absorption. Gastric lavage may be helpful in some cases. Clinically severe hypotension due to the overdose of this drug calls for active cardiovascular support, including frequent monitoring of cardiac and respiratory function and ensuring sufficient fluid volume like blood and urine output by pulling the limbs on a place higher than the body. A vasoconstrictor may be helpful in restoring vascular tone and blood pressure, provided that there is no contraindication to its use. Intravenous calcium gluconate may be beneficial in reversing the effects of calcium channel blockade. Amlodipine is unlikely to be removed by hemodialysis because it is highly combined with protein.
Losartan: Significant lethality was observed in mice and rats alter the administration of 1,000 mg/kg/single dose and 2,000 mg/kg/single dose, respectively. (About 44 and 170 times the maximum recommended human dose on a mg/m² basis.) Few data are available in regard to overdosage in humans. The most likely manifestation of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. If symptomatic hypotension should occur, supportive treatment should be instituted. Neither losartan nor its active metabolite can be removed by hemodialysis.