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Pregnancy: Category C. Both Imipenem and Cilastatin sodium cross the placenta and are distributed into cord blood and amniotic fluid in human. There are no adequate and controlled studies to date using Imipenem and Cilastatin sodium in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.
Lactation: Imipenem is distributed into milk. The drug should be used with caution in nursing women. If the drug is considered to use in nursing women, this patient should interrupt breastfeeding during therapy.
