Plendil Dosage/Direction for Use

The tablets should be taken in the morning, be swallowed with water and must not be divided, chewed or crushed. The tablets can be administered without food or following a light meal not rich in fat or carbohydrates.
Hypertension: The dose should be adjusted individually. Treatment should be initiated with 5 mg once daily. If necessary, the dose may be further increased or another antihypertensive agent added. The usual maintenance doses are 5 mg to 10 mg once daily.
Stable angina pectoris: The dose should be adjusted individually. Treatment should be started with 5 mg once daily, increasing to 10 mg once daily if needed.
Elderly patients: In elderly patients initial treatment with 2.5 mg daily should be considered.
Impaired renal function: Impaired renal function does not affect plasma concentrations of felodipine. No dose adjustment is required. However, Plendil should be used with caution in patients with severely impaired renal function (see Pharmacology: Pharmacokinetics under Actions).
Impaired hepatic function: Patients with impaired hepatic function may have elevated plasma concentrations of felodipine and may respond to treatment at lower doses.
Paediatric population: Felodipine should, due to limited clinical trial experience, not be used in pediatric patients.