Plendil Use In Pregnancy & Lactation

Fertility: Data on male and female fertility in patients are missing.
Pregnancy: Relevant data from treatment of pregnant women with Plendil is lacking. Plendil should not be used during pregnancy, as teratogenic effects have been seen in animal studies. Calcium antagonists may inhibit premature contractions in the uterus, but there is no definite evidence of delayed delivery in a full-term pregnancy. There is a risk of development of hypoxia in the foetus in hypotensive mothers and of decreased perfusion of the uterus, due to a redistribution of the blood flow through peripheral vasodilatation.
Lactation: Felodipine is excreted in the breast milk. If the mother uses therapeutic doses of felodipine, only a very small dose is transferred via the breast milk to the child. There is insufficient experience of treatment with felodipine during lactation for an assessment of the risks to the child. For this reason, Plendil should not be given during lactation. In cases where the medical benefit of continued treatment is considered to be greater than the risk, stopping lactation should be considered.