Dicofen Drug Interactions

Lithium, Digoxin: Diclofenac sodium may raise their plasma concentrations.
Diuretics: Diclofenac sodium may inhibit the activity of diuretics. Concomitant treatment with potassium- sparing diuretics may be associated with increased serum potassium levels, which should therefore be monitored frequently.
NSAIDs: Concomitant administration may increase the frequency of undesirable side effects.
Anticoagulants: Although clinical investigations do not appear to indicate that Diclofenac sodium affects the action of anticoagulants, there are isolated reports of an increased risk of hemorrhage in patients receiving Diclofenac sodium and anticoagulants concomitantly. Close monitoring of such patients is therefore recommended.
Antidiabetics: Clinical studies have shown that Diclofenac sodium can be given together with oral antidiabetic agents without influencing their clinical effects.
However, isolated cases have been reported of both hypoglycemic and hyperglycemic effects necessitating changes in the dosage of hypoglycemic agents during treatment with Diclofenac sodium.
Methotrexate: Caution is called for when NSAIDs are administered <24 hrs before or after treatment with methotrexate since blood concentrations of methotrexate may rise and the toxicity of this substance be increased.
Cyclosporin: May increase nephrotoxicity of cyclosporine.
Quinolone Antibacterials: There have been isolated reports of convulsions which may have been due to concomitant use of quinolones and NSAIDs.