Domepa Adverse Reactions

Infections and infestations: sialoadenitis.
Blood and lymphatic system disorders: hemolytic anemia, bone-marrow failure, leukopenia, granulocytopenia, thrombocytopenia, eosinophilia.
Endocrine disorders: hyperprolactinemia.
Psychiatric disorders: psychic disturbances including nightmares, reversible mild psychoses or depression, decreased libido.
Nervous system disorders: Sedation (usually transient), headache, paraesthesia, parkinsonism, VIIth nerve paralysis, choreoathetosis, mental impairment, carotid sinus syndrome, dizziness, symptoms of cerebrovascular insufficiency (may be due to lowering of blood pressure).
Cardiac disorders: bradycardia, angina pectoris, myocarditis, pericarditis, atrioventricular block.
Vascular disorders: orthostatic hypotension (decrease daily dosage).
Respiratory, thoracic and mediastinal disorders: Nasal congestion.
Gastrointestinal disorders: Nausea, vomiting, abdominal distension, constipation, flatulence, diarrhoea, colitis, dry mouth, glossodynia, tongue discolouration, pancreatitis.
Hepatobiliary disorders: Liver disorders including hepatitis, jaundice.
Skin and subcutaneous tissue disorders: Rash (eczema, lichenoid eruption), toxic epidermal necrolysis.
Musculoskeletal and connective tissue disorders: Lupus-like syndrome, mild arthralgia with or without joint swelling myalgia.
Reproductive system and breast disorders: breast enlargement, gynaecomastia, amenorrhea, lactation disorder, erectile dysfunction, ejaculation failure.
General disorder and administration site condition: Asthenia, oedema (and weight gain) usually relieved by use of a diuretic (discontinue methyldopa if oedema progresses or signs of heart failure appear), pyrexia.
Investigations: Positive Coombs test, positive tests for antinuclear antibody, LE cells and rheumatoid factor, abnormal liver-function tests, increased blood urea.
Inform the doctor any adverse effects occurring during therapy.