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Should take caution when methyldopa is used concomitantly with the following agents: Other antihypertensive drug: because of potentiation of increase of antihypertensive effect, side reactions or unusual manifestation of drug idiosyncrasy.
Anesthetics: dose reduction of anesthetics may be required. If hypotension occurs during anesthesia, it usually can be controlled by vasopressors.
Lithium: because of increasing of lithium toxicity.
Monoamine oxidase (MAO) inhibitors: because of causing excessive hypotension.
Amphetamines, other central nervous system (CNS) stimulants, tricyclic antidepressants: because antihypertensive effect may be antagonized and control of blood pressure may be lost.
Iron hematinic: because of decreasing plasma concentration and antihypertensive effect of methyldopa.
Oral contraceptive: because of increasing risk of vascular damage and difficulty in controlling blood pressure.
