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Use in the adult: Initiation of therapy: the usual starting dosage is 250 mg, 2-3 times per day, in the first 48 hours; then the daily dosage may be adjusted depending on response of each patient. To minimize the sedation, start dosage increases in the evening.
Maintenance therapy: The usually daily dosage is 0.5-2 g per day in 2-4 divided doses. The maximum recommended daily dosage is 3 g.
Concomitant usage of thiazide is recommended if the therapy has not been started with a thiazide or if effective control of blood pressure cannot be maintained with the daily dosage of 2 g of methyldopa.
Lower dose of methyldopa may be used in elderly or patients with kidney impaired renal function.
Use in the elderly: The starting dosage is 125 mg, 2 times per day; then increase slowly but not to exceed the maximum dosage of 2 g per day.
Use in the children: Initial daily dosage is 10 mg/kg of body weight, in 2-4 divided doses. The maximum dosage is 650 mg/kg or 3 g daily.
