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Acute overdose may produce hypotension with other responses attributable to brain and gastrointestinal malfunction (excessive sedation, bradycardia, constipation, flatus, diarrhea, nausea, vomiting).
In the event of overdose, treatment is usually symptomatic and supportive. When ingestion is recent, gastric lavage or emesis may reduce absorption. When ingestion has been earlier, infusions may be helpful to promote urinary excretion. Otherwise, management includes special attention to cardiac rate and output, blood volume, electrolyte imbalance, paralytic ileus and cerebral activity.
Sympathomimetic drugs (e.g.: levarterenol, epinephrine, metaraminol bitartrate) may indicated.
Methyldopa is dialyzable.
