Prevention of skeletal events in patients w/ advanced bone malignancies. Treatment of hypercalcemia of malignancy, Paget's disease of bone & osteoporosis in postmenopausal women.
Hypercalcemia malignancy 4 mg as single dose. May be repeated if necessary after at least 7 days at dose of 4 mg. Bone malignancies 4 mg (diluted) 3-4 wkly. Paget's disease 5 mg as single IV infusion. Osteoporosis in postmenopausal women 5 mg as single IV infusion, once a yr.
Ensure adequate hydration before & after therapy. Monitor serum Ca, phosphate, Mg & creatinine following initiation of therapy. Aspirin-sensitive asthma; concomitant use w/ drugs w/ renal toxicity. Discontinue use if renal function aggravates during treatment. Childn. Elderly.
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