Hendronic Adverse Reactions

The most common adverse reaction of zoledronic acid for injection is fever; other adverse reactions included: Body as a Whole: Asthenia, chest pain, leg edema, conjunctivitis.
Digestive: Nausea, vomiting, constipation, diarrhea, abdominal pain, dysphagia, anorexia.
Cardiovascular System: Hypotension.
Blood and Lymphatic System: Anemia, hypopotassemia, hypomagnesemia, hypocalcemia, hypophosphatemia, granulocytopenia, thrombocytopenia, pancytopenia.
Musculoskeletal: Ostealgia, arthralgia, myodynia.
Kidney: Increase in serum creatinine (relate to administration time).
Nervous System: Insomnia, anxiety, excitation, headache, somnolence.
Respiratory: Dyspnea, cough, hydrothorax.
Infections: Urinary tract infections, upper respiratory tract infection.
Metabolic System: Anorexia, weight loss, dehydration.
Others: Influenza-like symptoms, red swelling at injection site, rash, itching, etc.
Most of adverse reactions of zoledronic acid for injection are mild and transient. In most cases, no specific treatment is required and the symptoms subside after 24-48 hrs.