Overdosage may lead to clinically significant hypocalcemia, hypophosphatemia and hypomagnesemia. Clinically relevant reductions in serum levels of calcium, phosphorus and magnesium should be corrected by IV administration of calcium gluconate, potassium or sodium phosphate, and magnesium sulfate. Besides, overdosage increase the risk of renal toxicity. Single dose of zoledronic acid should not exceed 4 mg. Give milk or antacids to bind the bisphosphonate and minimize absorption during oral dosage.
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