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Hypercalcemia Malignancy: 4 mg as single dose. Treatment may be repeated if necessary after at least 7 days at dose of 4 mg.
Bone Malignancies: 4 mg, dilute as mentioned in the following texts, every 3-4 weeks.
Paget's Disease: 5 mg as single IV infusion.
Osteoporosis in Postmenopausal Women: 5 mg as single IV infusion, once a year.
Administration: Direction for Reconstitution: Zoledronic acid should be given by IV infusion. Adult patient should be given zoledronic acid 4 mg (1 vial) each time. Dilute with 100 mL of 0.9% sodium chloride injection or 5% glucose injection before use. The procedure of infusion should last not less than 15 min. It is administered at each 3-4 weeks or according to the physician's advice.
