Hendronic Special Precautions

Ensure adequate hydration before and after doses of zoledronic zcid as dehydration predisposes to renal function deterioration.
Serum levels of calcium, phosphate and magnesium, as well as serum creatinine, should be carefully monitored following initiation of therapy with zoledronic acid for injection. If hypocalcemia, hypophosphatemia or hypomagnesemia occurs, supplemental therapy may be necessary.
Patients with malignant hypercalcemia must be adequately rehydrated prior to the administration of zoledronic acid for injection. Loop diuretics should not be used until the patient is adequately rehydrated when it is used in combination with zoledronic acid for injection. Zoledronic acid for injection should be used with caution in combination with drugs which have renal toxicity.
If the renal function aggravate during the treatment, discontinue the medication until renal function recover to baseline.
Zoledronic acid for injection should be used with caution in patients with aspirin-sensitive asthma.
Use in children: The use in children is not recommended. The safety and effectiveness of zoledronic acid for injection in pediatric patients have not been established.
Use in the elderly: Medication is the same as adult. Carefully monitor renal function status when it is used in elders, because elders usually have the problem of lower renal function.