Given by IM, IV, intra-arterial or intrathecal route.
Choriocarcinoma & similar trophoblastic disease 15-30 mg daily IM for 5 days w/ rest periods of >1 wk. Requires 3-5 courses.
Leukemia 3.3 mg/m
2 IV w/ prednisone 60 mg/m
2 daily. Maintenance dose: 30 mg/m
2 orally or IM twice wkly, or alternatively 2.5 mg/kg IV every 14 days.
Meningeal leukemia Administer 12 mg/m
2 intrathecally.
Childn ≥3 yr 12 doses,
2 yr 10 doses,
1 yr 8 doses,
<1 yr 6 doses.
Mycosis fungoides 50 mg once wkly or 25 mg twice wkly.
Osteosarcoma Night dose therapy: 12 mg/m
2 may be increased to 15 mg/m
2 IV or IM at 24 hr after initial infusion. Take leucovorin 15 mg every 6 hr for 10 doses.
Psoriasis 10-25 mg/wk by IM or IV.
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