Alltrex Dosage/Direction for Use

Neoplastic Diseases: Methotrexate Injection B.P. (Preservative free) may be given by the intramuscular, intravenous, intra-arterial or intrathecal route.
Chorlocarcinoma and similar Trophoblastic diseases: 15 to 30 mg daily IM for 5 days, with rest periods of more than 1 weeks interposed between courses, until any manifesting toxic symptoms subside. Three to five courses usually required.
Leukemia: Methotrexate in combination with steroids is used for induction of remission of leukemias. Methotrexate in doses of 3.3 mg/m² IV in combination with prednisone 60 mg/m² FV7 daily has been used. When remission has been obtained, a maintenance doses of Methotrexate 30 mg/ms orally or IM twice weekly, or alternatively 2.5 mg/kg IV every 14 days may be given. The induction regime may be repeated if and when relapse occur. Acute granulocytic leukemias responds poorly to chemotherapy. Remissions are of short duration, relapses are common and resistance to treatment develops rapidly.
Meningeal Leukemia: For the treatment of meningeal leukemia, administer 12 mg/m² intrathecally. Dilute preservative-free Methotrexate to a concentration of 1 mg/mL with a sterile preservative-free 0.9% Sodium Chloride Inj. At intervals of 2 to 5 days and repeat until the cell count of the CSF returns to normal, may be given with close monitoring for toxicity. However, caution needs to be exercised as large doses may cause convulsions. Mainly neurological in character may occurs. The cerebrospinal fluid volume (CSF) is dependent on age and not on body surfaces area. The CSF is at 40% of the adult volume at birth and reaches the adult volume in several years. The following dose regimen is recommended for intrathecal administration of Methotrexate based on age instead of body surface area and appears to result in more consistent CSF Methotrexate concentrations and less neurotoxicity: see Table.

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Mycosis fungoides: Methotrexate IM doses of 50 mg once weekly or 25 mg two times weekly.
Osteosarcoma: The starting dose of Methotrexate for night dose therapy is 12 mg/m² and may be escalated to 15 mg/m² and given IV or IM Starting at 24 hrs after start of Methotrexate infusion, 15 mg leucovorin orally every 6 hrs for 10 doses is recommended.
Psoriasis: Weekly single IM or IV dose schedule of 10 to 25 mg per week until adequate response is achieved. Dose regimens used to treat psoriasis depending on the nature and severity of the condition. Severe uncontrolled psoriasis may respond to Methotrexate 10-25 mg per week by IM or IV.