Pharmacology: Methorexate inhibits dihydrofolic add reductase and interferes with DNA synthesis and cellular replication. Actively proliferating tissues such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa and cells of the urinary bladder are generally more sensitive to this effect of Methotrexate. Thus Methotrexate may impair malignant growth without irreversible without damage to normal tissues.
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