Methotrexate can cause teratogenicity or fetal death during pregnancy and is contraindicated in pregnant women and nursing mothers as it is excreted in milk. Methotrexate is contraindicated in patients with serious renal or liver disorders, blood dyscrasias like bone marrow hypoplasia, leukopenia, thrombocytopenia or significant anemia. Patients with known hypersensitivity to Methotrexate should not receive the drug.
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