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Symptom of fatal intoxication are anorexia progressive weight loss, bloody diarrhoea, leucopenia depression and coma.
Leucovorin is indicated to diminish the toxicity and counteract the effect of inadvertently administered over dosages of methotrexate. The dose of leucovorin should be equal to or higher than the offending dose of methotrexate and should be given as soon as possible preferably within the first hours after which time it is much less effective. Leucovorin may be administered by IV infusion in doses of up to 75 mg within 12 hours. Follow by 12 mg IM every six hours for four doses.
