Rontin Dosage/Direction for Use

General: Gabapentin can be given with or without food.
Discontinuation of gabapentin: In accordance with current clinical practice, if gabapentin has to be discontinued it is recommended this should be done gradually over a minimum of 1 week independent of the indication.
Epilepsy: Adults and pediatric patients over 12 years of age: The effective dosage of gabapentin is 900 to 3600 mg daily administered in 3 divided doses. Therapy may be initiated by titrating the dose as described in Table 1 or by administering 300 mg three times a day in Day 1. Thereafter, based on individual patient response and tolerability, the dose can be further increased in 300 mg/day up to a maximum does of 3,600 mg/day. The total daily dose should be divided in three single doses, the maximum time interval between the dose should not exceed 12 hours to prevent breakthrough convulsions. (See Table 1.)

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Pediatric patient age 3 - 12 years: The starting dose should range from 10 to 15 mg/kg/day in 3 divided dose, and the effective dose reached by upward titration over a period of approximately three days. The effective does of gabapentin in children age 5 years and older is 25 to 35 mg/kg/day. The effective dose in pediatric patients ages 3 to less than 5 years is 40 mg/kg/day. The total daily dose should be divided in three single dose the maximum time interval between doses should not exceed 12 hours to prevent breakthrough convulsion.
It is not necessary to monitor gabapentin plasma concentrations to optimize gabapentin therapy. Further, gabapentin may be used in combination with other antiepileptic medicinal products without concern for alteration of the plasma concentrations of gabapentin or serum concentrations of other antiepileptic medicinal products.
Neuropathic pain in adults: The therapy may be initiated by titrating the dose as described in Table 1, or by administering 300 mg three times a day. Thereafter, based on individual patient response and tolerability, the dose can be increased up to a maximum dose of 3600 mg/day.
Use in patients with renal impairment: The following dosages are recommended in patients with compromised renal function and/or those undergoing haemodialysis. (See Table 2.)

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Use in patients undergoing haemodialysis: For patients undergoing haemodialysis who have never received gabapentin, a loading dose of 300 to 400 mg is recommended, then 200 mg to 300 mg of gabapentin following each 4 hours of haemodialysis.