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Symptoms: Acute, life-threatening toxicity has not been observed in human with gabapentin overdose of up to 49 grams. In these cases, double vision, slurred speech, drowsiness, lethargy and diarrhea were observed. All patients recovered with supportive case.
Treatment: Reduced absorption of gabapentin at higher doses may limit drug absorption at the time of overdosing and, hence, minimise toxicity from overdoses.
Gabapentin can be removed by haemodialysis. Although haemodialysis has not been performed in the few overdose cases reported, it may be indicated in patients with significant renal impairment.
