Veflox Drug Interactions

500 mg: Antacid, Sucralfate, Metal Cations, Multivitamins: While the chelation by divalent cations is less marked than with other quinolones, concurrent administration of Veflox with antacids containing magnesium, or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc may interfere with the gastrointestinal absorption of levofloxacin, resulting in systemic levels considerably lower than desired. These agents should be taken least two hours before of two hours after levofloxacin administration.
Theophylline, Non-steroidal anti-inflammatory drugs: No pharmacokinetic interactions of levofloxacin were found with theophylline in a clinical study. However there are indications of a pronounced lowering of the cerebral seizure threshold when quinolones are given concurrently with other drugs that lower the seizure threshold (e.g. theophylline) or with fenbufen or similar non-steroidal anti-inflammatory drugs.
Antidiabetic agents: Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent. Therefore, careful monitoring of blood glucose is recommended when this agents are co-administered.
Anticoagulant drug (warfarin): Coadministration with warfarin has been reported that the effect of warfarin was potentiated (hepatic metabolism of warfarin may be inhibited, or free warfarin may be increased by competitive displacement from the protein binding site) and therefore prothrombin time prolonged.
750 mg: Concomitant use of levofloxacin and class IA (e.g., quinidine, procainamide) or class III (e.g., amiodarone, sotalol) antiarrhythmic agents has resulted in prolong QT interval.
Concomitant administration of levofloxacin with aluminum- or magnesium-containing antacids has resulted in decreased absorption of oral levofloxacin.
Concomitant use of levofloxacin and procainamide has resulted in increased half-life and decreased clearance of procainamide.
Concomitant use of levofloxacin and antidiabetic agents (e.g., insulin, glyburide) has resulted in altered blood glucose concentrations and symptomatic hyperglycemia or hypoglycemia.
Concomitant use of levofloxacin and corticosteroids increases the risk of severe tendon disorders (e.g., tendinitis, tendon rupture), especially in geriatric patients older than 60 years of age.
Concomitant use of levofloxacin and iron or multivitamins or mineral supplements has resulted in decreased absorption of oral levofloxacin.
Concomitant use of levofloxacin and nonsteroidal anti-inflammatory agents (NSAIAs) may increase the risk of CNS stimulation and seizures.
Concomitant use of levofloxacin and warfarin has resulted in increased prothrombin time.