Veflox Special Precautions

500 mg: Do not use in patients who are hypersensitive to levofloxacin or any other quinolone antimicrobial agents.
If skin rash, or muscle pain or tendon pain (e.g. at the wrist or ankle) occurs, discontinue levofloxacin and consult a physician immediately.
Levofloxacin could be harmful to the liver and kidneys.
Do not use, or if necessary, use with special precaution in patients with CNS disorder that predispose to seizures in a dose related manner.
Levofloxacin may prolong the QT interval therefore, use with caution in patients with a history of prolonged QT interval, patients at risk to develop prolongation of the QT interval such as elderly, patients with heart diseases, especially arrhythmia, patients with hypertension and patients with uncorrected electrolyte disorders (e.g., hypokalemia) etc.
Avoid coadministration with drugs that cause prolongation of the QT interval such as antiarrhythmic class IA (e.g. quinidine, procainamide), class III (e.g. amiodarone, sotalol), cisapride, erythromycin, antipsychotics drugs, tricyclic antidepressants, etc.
Levofloxacin may cause phototoxicity reaction or a severe rash, such as Toxic Epidermal Necrolysis, Stevens-Johnson syndrome, Erythema Multiforme, etc.
Levofloxacin may affect blood sugar levels. Carefully use in diabetic patients.
Coadministration of this drug with warfarin may increase the effect of warfarin.
Use in Pregnancy & Lactation: Avoid using levofloxacin in pregnant and breast-feeding women.
Use in Children: Levofloxacin may used be for inhalational anthrax (post exposure) in adolescents and children 6 months of age or older. Safety and efficacy do not established for any other indication in this age group. There is reported that levofloxacin causes arthropathy in juvenile animals use of so, fluoroquinolones may be justified in children younger than 18 years old.
750 mg: Levofloxacin should be avoided in patients who have a history of tendon disorders or have experienced tendinitis or tendon rupture.
Levofloxacin should be avoided in patients who have experienced peripheral neuropathy.
Levofloxacin should be used with caution in patients with known or suspected CNS disorders that predispose to seizures or lower the seizure threshold (e.g., severe cerebral arteriosclerosis, epilepsy) or with other risk factors that predispose to seizures or lower the seizure threshold (e.g., certain drugs, renal impairment).
Levofloxacin should be avoided in patients with a known history myasthenia gravis. Patients should be advised to immediately contact a clinician if they experience any symptoms of muscle weakness, including respiratory difficulties.
Levofloxacin should be avoided in patients with a history of prolonged QT interval, in those with uncorrected electrolyte disorders (e.g., hypokalemia), and in those receiving class IA (e.g., quinidine, procainamide) or class III (e.g., amiodarone, sotalol) antiarrhythmic agents.