Pregnancy: Category C. Avoid using levofloxacin in pregnant and breast-feeding women.
500 mg: Levofloxacin crosses the placenta. Quinolone exposure during human pregnancy has been reported with other agents. To date, no specific teratogenic effect or increased pregnancy risk has been identified; however, because of concerns of cartilage damage in immature animals exposed to quinolones and the limited levofloxacin specific data, levofloxacin should only be used during pregnancy if a safer option is not available.
750 mg: There are no adequate and well-controlled studies of levofloxacin in pregnant women, and the drug should be used during pregnancy only if the potential benefits justify the potential risk to the fetus.
Lactation: 500 mg: Enters breast milk, not recommended.
750 mg: Levofloxacin is distributed into milk following oral administration. Because of the potential for serious adverse reactions in the infant, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.