ECOXIB is contraindicated in: patients with known hypersensitivity to any component of this product; patients with active peptic ulceration or gastro-intestinal (GI) bleeding; patients with severe hepatic dysfunction (Child-Pugh score >9); patients with estimated creatinine clearance <30 ml/min; patients who have developed signs of asthma, acute rhinitis, nasal polyps, angioneurotic oedema or urticaria following the administration of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs); pregnancy and lactation; children under 16 years of age; patients with inflammatory bowel disease; patients with congestive heart failure (NYHA II-IV); patients with hypertension whose blood pressure has not been adequately controlled; patients with established ischemic heart disease, peripheral disease and/or cerebrovascular disease (including patients who have recently undergone coronary artery bypass graft surgery or angioplasty).
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