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Overdose and treatment: In general, symptoms of NSAID poisoning are mild, and usually include nausea and vomiting, epigastric, pain, tinnitus, headache, drowsiness, blurred vision, and dizziness. Gastrointestinal bleeding may also occur. There have been isolated case reports of more serious toxicity, including seizures, hypotension, apnoea, coma, and renal failure, although usually after ingestion of substantial quantities. Exacerbation of asthma may occur in asthmatics.
Treatment of NSAID overdosage is entirely supportive. The benefit of gastric decontamination is uncertain although activated charcoal may be of benefit within 1 hour of ingestion of a potentially toxic amount. Forced diuresis, haemodialysis, or haemoperfusion are unlikely to be of benefit for NSAID overdosage, although haemodialysis may be required if oliguric renal failure develops.
