Ecoxib Drug Interactions

Metabolism/Transport Effects: Substrate of CYP3A4 (major); Note: Assignment of Major/Minor substrate status based on clinically relevant drug interaction potential.
Avoid Concomitant Use: Avoid concomitant use of Etoricoxib with any of the following: Dexketoprofen; Floctafenine; Ketorolac (Nasal); Ketorolac (Systemic); Morniflumate; Nonsteroidal Anti-Inflammatory Agents; NSAID (COX-2 Inhibitor); Omacetaxine; Pelubiprofen; Phenylbutazone; Talniflumate; Tenoxicam; Zaltoprofen.
Increased Effect/Toxicity: Etoricoxib may increase the levels/effects of: 5-ASA Derivatives; Aliskiren; Aminoglycosides; Aminolevulinic Acid; Anticoagulants; Bisphosphonate Derivatives; Cyclosporine (Systemic); Deferasirox; Desmopressin; Digoxin; Drospirenone; Eplerenone: Estrogen Derivatives; Haloperidol; Lithium; Methotrexate; NSAID (COX-2 Inhibitor); Omacetaxine; Porfimer: Potassium-Sparing Diuretics; Pralatrexate; Quinolone Antibiotics; Tacrolimus (Systemic); Tenofovir Products; Tolperisone; Triflusal; Vancomycin; Verteportin; Vitamin K Antagonists.
The levels/effects of Etoricoxib may be increased by: ACE Inhibitors; Alcohol (Ethyl); Angiotensin II Receptor Blockers; Antidepressants (Tricyclic, Tertiary Amine); Aspirin; Corticosteroids (Systemic); Cyclosporine (Systemic); Dexketoprofen; Felbinac; Floctafenine; Herbs (Anticoagulant/Antiplatelet Properties); Ketorolac (Nasal); Ketorolac (Systemic); Loop Diuretics; Morniflumate; Naftazone; Nonsteroidal Anti-Inflammatory Agents; Pelubiprofen; Phenylbutazone; Probenecid; Selective Serotonin Reuptake Inhibitors; Sodium Phosphates; Talniflumate; Tenoxicam; Thiazide and Thiazide-like Diuretics; Tolperisone; Triflusal; Zaltoprofen.
Decreased Effect: Etoricoxib may decrease the levels/effects of: ACE Inhibitors, Aliskiren; Angiotensin II Receptor Blockers; Beta Blockers; Eplerenone; Hydralazine; Loop Diuretics; Potassium-Sparing Diuretics; Prostaglandins (Ophthalmic); Selective Serotonin Reuptake Inhibitors; Thiazide and Thiazide-like Diuretics.
The levels/effects of Etoricoxib may be decreased by: Bile Acid Sequestrants; Bosentan; CYP3A4 Inducers (Moderate); CYP3A4 Inducers (Strong); Dabrafenib; Deferasirox; Enzalutamide; Mitotane; Siltuximab, St John's Wort; Tocilizumab.