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Pregnancy Considerations: Adverse events have been observed in animal reproduction studies.
Etoricoxib is an NSAID that selectively inhibits COX-2 whereas other NSAIDs are nonselective for COX-1 and COX-2. The effects of selective inhibition to the fetus have not been well studied and no specific data for etoricoxib is available. Like other agents in this class that inhibit prostaglandin synthesis, etoricoxib may cause uterine inertia, premature closure of the ductus arteriosus, and adverse fetal events, and may affect fertility. Use during pregnancy is contraindicated; use in women who wish to become pregnant is not recommended.
Breast-Feeding Considerations: It is not known whether etoricoxib is excreted in human milk. Breastfeeding is contraindicated.
