Ecoxib Dosage/Direction for Use

Recommended Dose: ECOXIB is administered orally. ECOXIB may be taken with or without food. ECOXIB should be administered for the shortest duration possible and the lowest effective daily dose should be used.
Osteoarthritis: The recommended dose is 30 mg or 60 mg once daily.
Rheumatoid Arthritis: The recommended dose is 90 mg once daily.
Ankylosing Spondylitis: The recommended dose is 90 mg once daily.
Acute Gouty Arthritis: The recommended dose is 120 mg once daily.
Chronic musculo-skeletal pain, including chronic low back pain: The recommended dose is 60 mg once daily.
Acute Pain: For acute pain conditions, ECOXIB should be used only for the acute symptomatic period limited to a maximum of 8 days.
Post-operative Dental Pain: The recommended dose is 90 mg once daily.
Primary Dysmenorrhea: The recommended dose is 120 mg once daily.
Post-operative Gynecological Pain: The recommended dose is 90 mg once daily. The initial dose should be administered shortly before surgery. The dose can be increased to a maximum 120 mg once daily.
Doses greater than those recommended for each indication have either not demonstrated additional efficacy or have not been studied. Therefore, The dose for OA should not exceed 60 mg daily.
The dose for RA should not exceed 90 mg daily.
The dose for ankylosing spondylitis should not exceed 90 mg daily.
The dose for acute gout should not exceed 120 mg daily.
The dose for acute pain and primary dysmenorrhea should not exceed 120 mg daily.
The dose for chronic pain should not exceed 60 mg daily.
The dose for post-operative acute dental surgery pain should not exceed 90 mg daily.
The dose for post-operative acute gynecological surgery pain should not exceed 120 mg daily.
As the cardiovascular risks of selective COX-2 inhibitors may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used. The patient's need for symptomatic relief and response to therapy should be re-evaluated periodically.
Pediatric adolescents ≥16 years: Refer to adult dosing.
Note: Consider dosage reduction in adolescents <60 kg; similar pharmacokinetics have been observed between this population and adults; administered a 33% higher dose.
Renal Impairment: CrCl ≥30 mL/minute: No dosage adjustment necessary.
CrCl <30 mL/minute: Use is contraindicated.
Hepatic Impairment: Etoricoxib 120 mg tablet is not for use in mild and moderate hepatic impairment.
Mild hepatic impairment (Child-Pugh class A): Do not exceed 60 mg once daily.
Moderate hepatic impairment (Child-Pugh class B): Do not exceed 30 mg once daily or 60 mg every other day; use with caution.
Severe hepatic impairment (Child-Pugh class C): Use is contraindicated.
Mode of Administration: Oral: May be administered without regard to meals.